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Oncology and Liquid Biopsy Workflows| Sample Preparation

--- Kits, Raw materials, Automated machines ---


Oncology and liquid biopsy research workflows involve the analysis of circulating tumor DNA (ctDNA), cell-free DNA, and nucleic acids derived from challenging plasma and FFPE samples. Fragmentation, low abundance, and background noise require preparation systems that maintain consistency while preserving downstream sensitivity.

This page outlines sample preparation approaches supporting low-background plasma workflows and FFPE handling, enabling compatibility with qPCR, digital PCR, and next-generation sequencing research. Explore related product series below for workflow-aligned systems.


Ⅰ. Recommended Products

Cell Free DNA/RNA Kit

Liquid biopsy plasma workflow – cfDNA isolation (IVD3182)

HiPure Circulating DNA Kit
Isolation circulating DNA from 1-5ml plasma, serum, body fluids using vacuum protocol
High-volume plasma workflow – magnetic method (IVD5435)

MagPure Circulating DNA Maxi Kit
Isolation circulating DNA from 1-6ml plasma, serum, body fluids by magnetic method
Size-selection cfDNA workflow – remove >500 bp (12927)

MagPure Circulating DNA Rich Maxi Kit
Rich small fragment cfDNA from 5ml serum/plasma, remove DNA fragments>500bp

FFPE DNA/RNA Kit

FFPE tissue preparation workflow for oncology research

HiPure FFPE DNA Kit
Isolation total DNA from FFPE tissue samples
Magnetic bead workflow for FFPE tissue sample preparation

MagPure FFPE DNA Kit
Isolation total DNA from FFPE using high bind beads
High-purity FFPE workflow for downstream molecular analysis

HiPure FFPE RNA Plus Kit
Isolation total RNA from FFPE tissue and section samples (with DNase)
Co-isolation workflow for FFPE DNA and RNA preparation

HiPure FFPE DNA/RNA Kit
Co-Isolation DNA and RNA from a single FFPE tissue sample


FFPE co-extraction workflow for research application

MagPure FFPE DNA/RNA Kit
Co-isolation of total RNA and DNA from FFPE tissue using lysis-based separation, supporting improved RNA integrity.

FFPE co-extraction workflow for Oncology research

MagPure FFPE DNA/RNA Kit
Co-isolation of total RNA and DNA from FFPE tissue using sequential magnetic bead separation, enabling higher DNA/RNA recovery.

Columns/Magnetic Beads

Silica column component for sample preparation workflows

HiPure DNA Mini Column I
Designed for routine genomic DNA and RNA purification in standard laboratory workflows (2-layer GF/F membrane)




centrifuge method cfdna column set for cfdna workflows

HiPure cfDNA Column Set I (Centrifuge Method)
Designed for circulating DNA purification from plasma and other cell-free samples, compatible with both centrifugation and vacuum workflows, with sample input up to 5 mL (3-layer GF/F, 1-layer GF/B membrance)
vacuum method cfdna column set for cfdna workflows

HiPure cfDNA Column Set Ⅱ (Vacuum Method)
Designed for circulating DNA purification from plasma and other cell-free samples, compatible with both centrifugation and vacuum workflows, with sample input up to 5 mL (3-layer GF/F, 1-layer GF/B membrance)
Magnetic bead component for automated workflow compatibility

MagPure Particles F
Magnetic beads for large volume cell-free DNA/RNA isolation, 0.2-1.5um size silica beads
Magnetic bead component for automated workflow compatibility

MagPure Particles G
Magnetic beads for circulating/FFPE DNA/RNA isolation, 1~1.5μm size silica beads
Magnetic workflow component – cfDNA handling

MagPure A4 XP
Recover DNA from PCR & enzyme reactions (Replace Beckmen or agencourt Ampure XP) Can be used in NGS library construction

Machine

Automation platform for high-throughput sample preparation

MagMix 4 Maxi Extraction Machine
Large volume nucleic acid extractor, 24 well plate,single strip magnetic tip. 4 tests / plate, maximum treatment of 3x2ml sample, or 3x3ml sample
Automation platform for high-throughput sample preparation

MagMix 24 Maxi Extraction Machine
Large volume nucleic acid extractor, 24 well plate, 6 plates, 24 magnetic sleeves, 24 samples one time


Ⅱ. Experiment Data

IVD3182

Performance data in representative workflow conditions

Plasma cfDNA workflow figure for liquid biopsy sample preparation


IVD5435

Comparative performance data versus established benchmarks

High-volume plasma cfDNA workflow figure for downstream analysis



IVD3126

ffpe dna experiment



D6323B

Comparative performance data versus established benchmarks



IVD5116

Comparative performance data versus established benchmarks

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