CN
111.png
banner
Your present location:Home/About us/News/Marketing/Magen FFPE/Universal kit adopted on Cancer Cell

Magen FFPE/Universal kit adopted on Cancer Cell

Release date:2024-03-25

Individualized tumor-informed circulating tumor DNA analysis

for postoperative monitoring of non-small cell lung cancer


Published: September 07, 2023DOI:https://doi.org/10.1016/j.ccell.2023.08.010

Summary

We report a personalized tumor-informed technology, Patient-specific pROgnostic and Potential tHErapeutic marker Tracking (PROPHET) using deep sequencing of 50 patient-specific variants to detect molecular residual disease (MRD) with a limit of detection of 0.004%. PROPHET and state-of-the-art fixed-panel assays were applied to 760 plasma samples from 181 prospectively enrolled early stage non-small cell lung cancer patients. PROPHET shows higher sensitivity of 45% at baseline with circulating tumor DNA (ctDNA). It outperforms fixed-panel assays in prognostic analysis and demonstrates a median lead-time of 299 days to radiologically confirmed recurrence. Personalized non-canonical variants account for 98.2% with prognostic effects similar to canonical variants. The proposed tumor-node-metastasis-blood (TNMB) classification surpasses TNM staging for prognostic prediction at the decision point of adjuvant treatment. PROPHET shows potential to evaluate the effect of adjuvant therapy and serve as an arbiter of the equivocal radiological diagnosis. These findings highlight the potential advantages of personalized cancer techniques in MRD detection.

For detail information, pls visit here

Related Products:

MagPure FFPE DNA Kit

CAT NO PRODUCT NAME SIZE PRICE
D632301B MagPure FFPE DNA Kit 48 preps $199.00
D632302B
MagPure FFPE DNA Kit
96 preps
$373.00

Introduction

This product is suitable for rapid extraction of DNA from FFPE sample, tissue, cells, blood, swabs, blood spots, semen and other clinical samples. This product uses size selection magnetic beads, which can selectively remove small sizes of DNA (100-300bp) from FFPE samples by adjusting the amount of binding solution, so as to improve the effective data volume of downstream NGS.

MagPure Universal DNA Kit

CAT NO PRODUCT NAME SIZE PRICE
IVD3102 MagPure Universal DNA Kit 200 preps $448.00

Introduction

This product is suitable for rapid extraction of DNA from tissue, cells, blood, saliva, swabs, blood spots, semen and other clinical samples. DNA can be used directly for PCR, quantitative PCR, Southern Blot, test of virus DNA and so on.

Back to list
Leave A Message

Leave A Message

    Please provide us with the information below, and we'll contact you as soon as possible.

This site uses cookies to improve your online experience,allow you to share content on social media,measure traffic to this website and display customised ads based on your browsing activity.