Homogenizing Tube/ Bead Tube

Mechanical homogenization is a critical step in nucleic acid sample preparation, particularly for samples that are difficult to lyse such as microbial cells, plant tissues and complex biological matrices. In these workflows, bead-based disruption provides rapid and reproducible sample processing prior to downstream purification.

Magen pre-filled bead tubes integrate optimized bead compositions, sizes and chemical components for different sample types. Depending on the application, these tubes support efficient bacterial and fungal cell disruption, tissue homogenization and challenging sample processing such as stool or pathogen-containing materials. Some configurations combine mechanical grinding with chemical lysis components to improve disruption efficiency.

By standardizing bead composition and workflow conditions, these systems reduce variability between samples and improve consistency in downstream column and magnetic bead–based nucleic acid extraction workflows.

The homogenization tube contains different grinding beads. It is recommended to choose a suitable homogenization tube for different samples and use it cooperated with the MagMix A vortex/bead grinder for bead grinding, which can effectively lyze samples which are difficult to lysis.

Extraction process

It is recommended to cooperated with the MagMix A vortex/bead grinder, whith 2ml centrifuge tube fixture, which can efficiently process 10-20 samples at once. The lysis time should be as short as possible to avoid shearing time and minimize the release of humic acid. It may be advantageous to increase the bead grind lysis time to 15-30 minutes according to the different samples, microbial community characteristics, and downstream applications.

Product features and advantages

Gentle and effective: using specialized disposable homogenization tubes to reduce sample contamination and achieve high purity and high recovery

Time and effort saving: By using the MagMix A vortex with a homogenizer tube, 24 samples can be efficiently processed at one time

User safety: Adopt a closed system in bead grinding and lysis for some infectious samples to protect the safety of experimental operators

Reliable results: Different samples are paired with different homogenates to reduce human error and ensure high reproducibility of the results

Convenient and flexible: By adding difficult-to-lyzed samples and lysis buffer, the beads can be directly grinded on the machine