MagPure Particles G

MagPure Particles G are designed for nucleic acid purification from low-input and small-volume circulating DNA (cfDNA) samples. The system supports stable adsorption of fragmented DNA under controlled binding conditions, enabling consistent recovery in workflows where sample input is limited.

Compared with large-volume extraction systems, MagPure Particles G are optimized for efficient handling of small plasma volumes, providing reliable performance in routine cfDNA processing and fragmented DNA applications.

For large-volume plasma or high-recovery cfDNA workflows, MagPure Particles F may be considered as an alternative system with enhanced recovery efficiency.

Specifications

Principle

Highsalt mediated binding: in the solution containing 2-4M guanidine isothiocyanate, Magpure particles can selectively recover DNA molecules, and impurities such as protein polysaccharides are not adsorbed.

Alcohol mediated binding: in the solution containing guanidine salt and alcohol (>25%), Magpure particles can selectively recover DNA/RNA molecules, and proteins and other impurities are not adsorbed.

After biological samples are treated with digestive solution or lysis Buffer, DNA/RNA is released from cells, organelles and protein complexes (ribosomes and nucleosomes) into reagents. After Magpure particles and binding solution are added, DNA/RNA is adsorbed to the surface of Magpure particles to form DNA/RNA bead complex. Under the action of the magnetic field, the magnetic beads are separated and collected, and the impurities such as protein are removed with the waste liquid. After two or three steps of further cleaning, the DNA/RNA magnetic bead complex is resuspended in sterilized water or TE buffer, and the DNA/RNA falls off from the surface of the magnetic beads, so as to achieve the purpose of purification.

Ordering information

Related Bead Selection

• MagPure Particles N (C1411)

  → Recommended for viral nucleic acid and low-abundance samples

• MagPure Particles F (C1414)

  → Optimized for large-volume plasma and high-yield cfDNA extraction

• MagPure Particles (C1410)

  → General-purpose DNA/RNA extraction workflows

For full comparison across all magnetic bead systems, refer to the Magnetic Bead Selection Guide.